Dilemma fue
Tuesday, September 14, 2010
AHRS meet at Mt. Abu ON 11TH SEPTEMBER
Thursday, July 8, 2010
8 new genes found associated with Alopecia areata
According to the study published in
the July issue of Nature the professor of dermatology and genetics at
Columbia, Angela Christiano et al have found
a connection between the gene called ULBP3 on Chromosome 3 and the
Alopecia Areata recently. This gene is normally not found in the hair follicles
but it was observed that ULBP3 proteins were found in high concentrations in
hair follicles affected by alopecia areata. ULBP3 attracts immune cells (called
cytotoxic cells, Natural Killer or NK Cells)
receptors called NKG2D . If an infection is present in the body, cytotoxic
cells can help fight the infection or
destroy damaged cells, but if there is no infection or damage, these immune
cells end up attacking healthy tissue. These genes ULBP3 are already associated
with a number of autoimmune disorders, including type 1 Diabetes & Rhematoid Arthritis.
Two other genes were also expressed
in hair follicles, while the remaining five genes were involved in immune
system response.
The researchers discovered that the number of
alopecia-associated genes a person had correlated with the severity of the
condition. Those who carried 16 or more genes (the genes are in pairs) were
more likely to progress to alopecia universalis, or total hair loss.
In people with alopecia, immune system T cells are present in large numbers in the hair follicle. Microscopic look is like the hair follicle is being attacked by bees, which are the T cells. Among the eight genes, one in particular -- ULBP3 -- has been shown to attract toxic cells that can invade and destroy an organ. In a person without alopecia, ULBP3 is turned off. But in people with alopecia, ULBP3 proteins are plentiful in the follicle.
In people with alopecia areata, a
huge expression of the ULBP3 gene in the outermost layer of the follicle is
seen as per Christiano. ULBP3 is a
danger signal that signals to T cells to come in and attack the follicle. It's
like putting nectar on the hair follicle, and then the 'bees' come in and do
their damage.
When the follicle is attacked, the
hair falls out. If the T cells remain, which they do in alopecia areata, the
follicle goes dormant.
The mechanism of genes pathway in
Alopecia areata has opened a new vista of developing the new drug for this
disease that affects over 5 million people only in America the disease is life-altering - sufferers,
especially children, experience social stigma. It affects their quality of life
and can lead to long-term psychosocial impact.
More over ULBP3 genes might work as
a biomarker for Alopecia areata.
Saturday, July 3, 2010
We perform procedures from Monday to Thursdays only and on Friday we have only consultations. Saturday and Sundays the clinic remains closed.
The usual policy FOR booking a date is:
You need to deposit $ 500 or 20000 Rupees in advance by one of the following: Following are the safe methods for sending advance deposit:
1. If you are in India you can deposit the amount to the Savings bank account of BISHAN MAHADEVIA at ICICI bank account No. 029501515482, ICICI bank SG Road Branch, Ahmedabad, Gujarat, India. You may deposit by cash or cheque by going to nearest ICICI bank or by sitting at home through Internet Transfer (NEFT) (Postal address: ICICI Bank Sarthik II, Ground Floor, S.G.Road, Bodakdev, Ahmedabad 380054 )
IFSC (Indian Financial System Code)code: ICIC0000295
MICR (Magnetic Ink Character Recognition) Code: 380229009
International wire transfer to this ICICI bank account in India is routed through one Correspondent Bank depending upon the currency that you are paying in (e.g. JP MORGAN CHASE, NEW YORK for payment in $ --- the comprehensive list is given at this link http://www.icicibank.com/pfsuser/icicibank/ibank-nri/nrinewversion/money_transfer/common/wire_transfer/wiretransfer_list.htm) You need to tell your bank the Name of Correspondent Bank, Account Number ,Swift code / BIC or IBAN or Bank Clearing Code of that branch of Correspondent bank to your local bank for the wire transfer form as mentioned in the "For a sample wire transfer form please select currency below" at this link http://www.icicibank.com/pfsuser/icicibank/ibank-nri/nrinewversion/money_transfer/money_transfer_others/wire_transfer.htm IBAN(International Bank Account Number Swift (Society for Worldwide Interbank Financial Telecommunication) code: or BIC ( Bank Identifier Code )
2. Bank Draft in favour " Dr. Bishan Mahadevia" payable at Ahmedabad
3. If you are out of India You can deposit the amount to my ICICI account 029501511589 by going to the nearest ICICI bank or by Bank to Bank Internet Transfer
4. Western Union: Deposit the amount at the nearest "Western Union" office payable to "DR. Bishan Mahadevia" at Ahmedabad, India. You will be given a 10 digit "MTCN number" that you have to pass on to me so that money can be encashed at my end of Western Union.
5. Ask your bank to Transfer the Fund Electronically in our current account in the name of Dr. Bishan Mahadevia of at HDFC Bank Navarangpura Branch, Ahmedabad: A/C number: 00062020002040. BIC: HDFCINBBAHM; IFSC code: HDFC 0000006
International wire transfer to this HDFC bank account is routed through one intermediary international bank e.g. JP Morgan Chase Bank and that bank depends upon the currency in which you are paying. You need to tell your bank the swift or IBAN code of that intermediary bank to your local bank as follows:
Swift Code for $ : CHASUS33 JP Morgan Chase Manhattan Bank of NY
Swift code for Pound: CHASGB2L JP Morgan Chase Manhattan Bank of NY
Swift code for Euro: CHASDEFX Gen ac No. 6231602308 JP Morgan Chase Manhattan Bank, Frankfurt
6 . Paypal.com: you should be the registered member of Paypal.com services or else go to www.paypal.com get registered. The Registration process takes 2-3 days for validation of your credit card and bank. After that you may send me the money directly to my e mail "info@goodbyehairloss.com" using "send money" option in www.paypal.com
N.B.:
1. In case of cancellation or changing the date you must inform us 1 week in advance if you want the refund. There will be no refund of advance in last week or on no show.
2. In case where deposit is not paid after taking a date the date will automatically canceled one week prior to the date and it can then be allocated to some one else.
We perform procedures from Monday to Thursdays only and on Friday we have only consultations. Saturday and Sundays the clinic remains closed.
ROUTINE PREOPERATIVE CARE
ROUTINE PREOPERATIVE CARE: advised to our hair transplant patients
1. Avoid smoking few days before and after
2. Avoid blood thinning medications like aspirin for a few days before if
possible
3. Wear regular shirt at the time of procedure and avoid T shirt
or thermal under garment which you have to wear from the top
4. Keep a large size cap or hat that yu may wear for a few days after
the procedure when you go outdoors.
5. Shampoo your hair well before coming for the
procedure
6. Do not come on empty stomach have good breakfast
or lunch before the procedure.
7. Exercise of the scalp skin: slide your skin up
and down on the back and side of the head by holding it with the palms of the
hands. You may be 100 times a day. This will increase its blood supply and also
make it more lax and makes the stitches tension free and thereby improves the quality of linear scar.
8. The routine preoperative blood tests (they include CBC,
Blood Sugar Urea, Hbs Ag, HIV, PT and APTT). You can get them done from the
Laboratory from your Town/City before coming if you want to save that time and also make sure the fitness for the surgery.
9. If you do have gray hairs get your hair colored black if possible for
surgical convenience before 2 days of procedure if not then inform us and come
earlier so that we can colour the donor area hairs prior to the procedure.
10. If you are going to have Body hair Transplant (BHT) you
must shave
the possible body donor areas ( chest, pubic, armpit, back or thighs) hairs to
the skin level exactly 4 days in advance of your procedure date.
10. Although rare there is a possibility of “shock loss” of
some of the currently existing weak hairs in first few months after the surgery
and If you are not already on Finasteride ( Tab. Finax 1mg or Propecia 1mg
to be taken once a day) start at earliest to protect your existing hairs.
10. I would appreciate if you can CALL ME A DAY BEFORE TO
MAKE SURE EVERYTHING IS OK ON MY MOBILE 9974113377
11. The black and white receipt you can receive when you
come for the procedure
Sunday, June 27, 2010
New advances in Asian Hair Transplantation workshop at Bangkok
Saturday, June 5, 2010
Tuesday, May 25, 2010
Photos of our clinic
Dr. Mahadevia' Hair Transplant Clinic
Procedure in progress
Consulting area
Waiting area
Our well trained and experienced Team
Monday, May 24, 2010
Gray hair, White Hair, Silver Locks, Achromotrichia or Canitis: Treatment and solutions
Gray or White
hair at young age can be a distressing and annoying at times for many but for
older people, gray hair can symbolize wisdom and maturity. Graying may make one
look older. Good news is recently, scientists have found that graying hair
might be protecting you from
getting cancer.
You will observe the first grey hairs usually near
the temples, then to the crown and then at the back of your head. The common belief that for every
graying hair they remove, two will grow back up in place of the lost one is a myth.
Hair color comes from a protein and a pigment called melanin. The cells in the hair follicles that make and store melanin are called melanocytes. The melanocytes also present in the basal layer of the epidermis that produces melanin under the control of the melanocyte-stimulating hormone
The stem cells at the base of hair follicles produce melanocytes. Melanocytes are also present in your hair follicles
right next to the dermal sheath, an area below the hair bulge where you can
also find keratinocyte cells. Working
synchronously, melanocytes and keratinocytes are the building blocks of your
hair
Hair color is the pigmentation of hair follicles due to two types of melanin,eumelanin and pheomelanin. Generally, if more melanin is
present, the color of the hair is darker; if less melanin is present, the hair
is lighter. Levels of melanin can vary over time causing a person's hair color
to change, and it is possible to have hair follicles of more than one color.
Pheomelanin colors hair red. Eumelanin, which has two subtypes of black
or brown, determines the darkness of the
hair color. A low concentration of brown eumelanin results in blond hair,
whereas a higher concentration of brown eumelanin will color the hair brown.
High amounts of black eumelanin result in black hair, while low concentrations
give gray hair. All humans have some pheomelanin in their hair.
Gray hair results from a reduction of pigment. White
hair has no pigment. Changes in hair color typically occur naturally as people
age, eventually turning the hair gray and then white. This is called achromotrichia.
There is a pocket that houses melanocyte stem cells
halfway up the follicle, above the bulb. These stem cells turn into melanocytes
when old melanocytes die off. The death or inactivity of the melanocyte stem
cells causes the onset of graying.
Causes:
Aging: No available treatment – only solution is colour the
hair.( white people will begin to gray in their mid-thirties and Asian people
begin graying in their late thirties, but most black people can retain their
original hair color until their mid-forties.) Your chance of going gray
increases 10 to 20 percent every decade after 30 years. By age 50, most people can expect 50 percent of
their hair to be gray.
There are two theories of aging. The signs of aging are programmed in our genes or DNA.
The second is that our cells and DNA wear out and get damaged over time
eventually leading to aging and the end of life. If we can find damage to the
DNA or cells dying as we get older, then maybe genes are not involved in aging. Some people believe as we get a
little bit older we don't produce enough catalase and then the hydrogen
peroxide cannot be broken down and that bleaches your hair from the inside out,
turning it gray
Premature
graying: This
premature graying of hair is called canities
in medical terminology How fast your hair turns grey really depends on the
person's genetic predisposition and certain lifestyle factors that can directly
influence the production of the pigment melanin. If you have a family history
of premature grey hairs, the chances of your hair turning graying much earlier
in life is far greater.
Genetic: No available treatment - only
solution is colour the hair. Two genes appear to be responsible for the process
of graying, Bcl2 and Bcl-w. Gene therapy may someday help us
treat the signs of aging
Smoking: Smokers were found to be four times
more likely to begin graying prematurely, compared to nonsmokers.
Lack of sleep and excess stress: Excessive stress is the principal
creator of chronic free radical damage that can damage vulnerable cells
like Melanocytes and influence melanin production.
Malnutrition:(certain Minerals cupper,
zink etc. and Vit B deficiency) is
also known to cause hair to become lighter, thinner, and more brittle. The
condition is reversible with proper nutrition.
Pernicious Anemia (Vitamin B12deficiency): Facing a deficiency in vitamin B
especially B12 has been associated with less effective hair pigmentation
Thyroid deficiencies: Hyper or Hypo
Thyroid status
Vitiligo (a patchy loss of hair and skin color that may occur as the result of an auto-immune disease.)
Werner Syndrome (premature
aging disease that begins in adolescence or early adulthood and results in the
appearance of old age by 30-40 years of age)
Apart from this
spicy, oily, fast or junk foods, addictive foods like tea, coffee, alcohol and
long illnesses, some medications etc are blamed to be the cause of premature
graying.
Grey
Hair Treatments
Given the
currently available treatment options, it appears that the greying process
cannot be effectively reversed. There is no scientific evidence at the moment
that any existing medicine, diet, herb, supplement or natural product can
prevent or reverse greying hair. The only current option that delivers
satisfactory results is changing the colour of your existing hair. You can
either use regular hair dyes or try progressive hair colorants. Unlike regular hair dyes, progressive hair colorants only affect your grey hair and not your
non gray hair, changing its colour gradually and unnoticeably. It makes their
hair look more natural, as they do not have to cover up all their grey. One interesting point about gray hair is
that it is thicker and usually grows faster than normal, pigmented hair, which
makes it more visible and difficult to cover with colour.Gray hair may temporarily darken after inflammatory processes, after electron-beam-induced alopecia, and after some chemotherapy regimens. However, French scientists treating chronic myeloid leukaemia (CML). patients with a new cancer drug Gleevec or Glivec noted an unexpected side effect: some of the patients' hair color was restored to their pre-gray color.
Nonetheless, there are some traditional and commercial products that claim to be effective in preventing and reversing graying hair.
Some
of them are:
Topical liquid, cream or foam, foam, oil, lotion or spray
GRECIAN FORMULA
GREYBAN
(POLY) RE-NATURE
RE:NUAL SERUM
RESTORIA
TOUCH OF GRAY
Oral Tabb or powder
MELANCOR-NH
REMINEX
SHEN MIN
SH SHOU WU PILL
OU WU PIA
Beggan's
pills
Go
Away Gray
YOUTHAIR
Active
Substances Used in these products are: 
FO-TI or He Shou Wu (polygonum multiflorum)a
Chinese herb also known
as Chinese knotweed or flowery knotweed, There is no clinical
research available supporting the claim of its efficacy
PABA
(para-aminobenzoic acid) is often referred to as vitamin BX or B10 and it is believed to be an anti-aging and
anti-grey hair vitamin.
FOLIC ACID is
another member from the group of vitamins B (B9)
An average healthy person is unlikely
to register a change in the colour of their hair as a result of the extra
intake of these two vitamins. Their administration can only be beneficial in
rare, grey hair conditions caused by the deficiency of any of these two
vitamins.
Amla or Indian Gooseberry
An Indain Fruit known as 'Amla'. You can make gooseberry oil and apply it to the scalp. To make the oil, you need to heat some amount of coconut oil with few pieces of the Indian gooseberries. After the berries turn dark, turn off the heat and let the solution cool down. Remove the berries and apply the oil to your hair.
An Indain Fruit known as 'Amla'. You can make gooseberry oil and apply it to the scalp. To make the oil, you need to heat some amount of coconut oil with few pieces of the Indian gooseberries. After the berries turn dark, turn off the heat and let the solution cool down. Remove the berries and apply the oil to your hair.
Blackstrap Molasses
Molasses is made out of sugarcane or sugar beets juice. The juice is boiled at high temperatures which crystallizes the sugars. When the left over liquid is heated up two more times, blackstrap molasses is formed. Blackstrap molasses also contains such as calcium, iron, magnesium, copper, potassium etc.
APPLE
CIDER VINEGAR -
its water solution applied topically. It is an old wive’s tale assumed to work
in a similar fashion to the metallic-based, hair colorants, gradually changing
the colour of white hair. Its mechanism of action and potential efficacy are unknown.
SAGE TEA
is another traditional natural remedy Strong sage tea should be applied to the
hair and left to dry, then rinsed with water and dried. This therapy should be
repeated weekly until the desired shade is achieved. It is conceivable that the
strong sage tea could stain and colour.
Wheat grass
(contains all essential
minerals the body needs)
Sea weeds (kelp, nori, dulse)
Sea weeds (kelp, nori, dulse)
Catalase: It is believed by
some that as we get a little bit older we don't produce enough of enzyme called
catalase and then the hydrogen peroxide cannot be broken down and that bleaches
your hair from the inside out, turning it gray. Products like Go away gray and
Beggan Pills have this as a main ingredient
Emu oil: supposed to moisturize and preserve
the hair nutrients like Omega3 and Vit B12
Other
Treatments:
RUBBING
THE NAILS
an old technique from India against each
other is said to help circulation (as nerve endings are located under the
finger nails
Henna (Mehdi) :Dried
Henna powder from henna leaves of the plant has been used traditionally in
India as temporary body decoration or tattoos.
It is also used to color the hair. It gives brownish red colour. Benefit
is believed to be it is a natural product and there is no synthetic pigment.
One of the ways to use is:
Henna is okay if you don’t have clorinated water, or go into swimming pools as
it will turn green or purple with the chemical reaction. It builds up and does
exactly what i told you henna will when exposed to chlorine. A temporary hair
color does a good job, and covers all the hair. The bonus is it will give
shine, and make the other hair more lusterious conditioning also.
Usage of henna powder is also one the
effective methods for gray hair treatment. Prepare a mix of henna powder (2
tbsp.), yogurt (1 tsp.), fenugreek seed powder (1 tsp.), coffee (3 tsp.), basil
juice (2 tsp.) and mint juice (3 tsp.). Use this mix to massage the scalp and
let it stay for about 3 hours. Thereafter, get your hair washed with a mild
shampoo
Hair color Dye or Colour
Covering or colouring Gray Hair
Although dyes
are a simple and fast solution for grey hair, using it too often can be a
potential health hazard for you. Conventional hair dyes are laden with
synthetic chemicals and carcinogens that can do more harm than good in the long
run. Bear in mind that dyes that are darker in color can contain significantly
more damaging chemicals like Phenylenediamine (PPD) than those with
lighter shades.
The Types of Hair Colouring
Semi-permanent hair color cannot
lighten hair. Hair can only be lightened using chemical lighteners, such as
bleach. Bleaching is always permanent because it removes the natural pigment. Select a hair color that is two shades lighter than your natural hair
shade, so that it blends well with the gray hair strands.
There are many options for what you can do with your hair 1.Color/ Bleaching 2. Highlighting/Lowlighting 3.Tinting 4. Re-Coloring
There are 5 types of hair color which are
Temporary Hair
Dyes
Usually comes in the form of
rinses, gels, mousses and sprays and majority of these products do not
penetrate or modify the structure of the hair shaft. They work like surface
paint as the molecules usually stay on the outer surface of the hair. In most
cases, you can usually wash the color
off immediately with a single shampooing. If you just want to experiment
with a different hair color, or color for some occasion temporary hair dyes
might be the safest and least harmful way to go for.Semi Permanent Hair Dyes
Demi-permanent hair Dyes: contains
no ammonia but is mixed with the developer (peroxide) shortly before
application. The developer helps lift the cuticle so that the colour can be
deposited outside and inside the cuticle and on the cortex. The molecules of demi-permanent hair
colours are very small and they are
therefore gradually washed out from the cortex, lasting about 15-20 shampoos.
Permanent Dyes
- Oxidization Dyes
To permanently change your hair color, you will require the use of dye intermediates like PPD and a developer containing hydrogen peroxide for oxidization. Both of these are mixed together before application and the chemicals will cause your hair cuticle to swell so that the coloring agents can easily penetrate through. Once inside your hair shaft, the agent will break up your original color pigments known as melanin and replaces it with the new color. In most cases, the color change is very permanent. - Progressive Hair Colorants
or Dyes
A progressive hair dye is another kind of permanent dye that changes your original hair color gradually by regular application. The dye contains metallic salts or organic compounds like lead acetate, bismuth citrate or 5,6-dihydroxyindoline which can easily absorb into your hair shaft and react with the structure of your hair. Over time, the lead will replace the color of your hair with the new color.
The Dangers in Hair
Dyes
Para-Phenylenediamine
(PPD)
The most common and
potent ingredient commonly known to cause allergic reactions well known carcinogen (cancer causing agent) after oxidation with the developer like Hydrogen Peroxide or Ammonia. non-Hodgkin's lymphoma, Multiple myeloma, Breast Cancer, Leukemia,
Coal Tar
allergic reactions
Lead Acetate
used for progressive dyes that change your
hair color gradually, is banned from cosmetics in the European Union and is a
potential carcinogen. Lead is said to be able to disrupt the function of your
brain's neurotransmitters and might also- Disrupts your
heart activity
- Causes blood
clots
- Reduces
intelligence
- Affects
sensory and motor developments
- Other
neurological problems
If
you are pregnant, then avoid lead products totally because it has been reported
to be able to cross the placenta and the embryo that can lead to fetal
mortality. That is why lead in the first place was banned from so many products
like paint.
Other Health Risks
in Hair Coloring
- DMDM Hydantoin
linked with causing immune system problems. - Ammonia
Widely used in fertilizers, plastics and explosives, ammonia is toxic and corrosive. This chemical can cause running nose, coughing and respiratory problems if inhaled, skin inflammations. - Resorcinol
used for oxidation and is an irritant and also a potential carcinogen.
Reduce Your Risk
NOW
Ecocolors or some
other natural hair dyes like henna that do not contain harmful chemicals. Some high end salons also use high tech equipment like infrared to open up the hair shaft for the color to absorb through rather than using oxidizers like peroxides and ammonia.